In truth, we discovered no vital differences in glucose AUC, HOMA-IR or ISI between lysine supplementation and control. More particularly, lysine supplementation had no affect endogenous glucose Ra (reflective of hepatic insulin sensitivity) or glucose Rd (indicative of peripheral insulin sensitivity). The MCR of glucose was also similar in the control, 2 L and 5 L, highlighting the shortage of any difference in the quantity of lysine ingestion on glucose kinetics.

Then, the target proteins or subdomains of them containing the goal lysine could be produced recombinantly and the methylation also examined at protein level. The horizontal axis represents the H3 sequence and the vertical axis represents the amino acids by which the corresponding row is mutated. A) Discrimination elements of NSD1 for the popularity of amino acid residues on the positions subsequent to the target lysine (K36 within the experiment shown here).

Amongst them we identified histone H3 lysine 27 acetylation (H3K27Ac) as a modification upregulated in CRC