Dit zal pagina "Anabolic Steroids StatPearls NCBI Bookshelf" verwijderen. Weet u het zeker?
Anabolic Steroids StatPearls NCBI Bookshelf
columbuslira2 heeft deze pagina aangepast 1 dag geleden
Anabolic Steroids StatPearls NCBI Bookshelf
Anabolic Steroids: Pharmacology, Clinical Use, and Safety Considerations
---
- What is the mechanism of action for anabolic steroids?
StepMechanismResult
- Cellular uptakeLipophilic steroid enters cell via passive diffusion or carrier‑mediated transport.Steroid reaches cytoplasm.
- Nuclear bindingDissociates from heat‑shock protein complexes → binds directly to the intracellular androgen receptor (AR).AR–steroid complex forms.
- DNA transcriptionComplex translocates to nucleus, attaches to androgen response elements (AREs) on target gene promoters.Recruitment of co‑activators (p300/CBP), histone acetyltransferases → chromatin remodeling.
- Gene expressionInitiation of mRNA synthesis for anabolic proteins: IGF‑1, myosin heavy chain, creatine kinase, etc.
Verwijder pagina