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Anabolic Steroids StatPearls NCBI Bookshelf
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Anabolic Steroids StatPearls NCBI Bookshelf
Anabolic Steroids: Pharmacology, Clinical Use, and Safety Considerations
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- What is the mechanism of action for anabolic steroids?
StepMechanismResult
- Cellular uptakeLipophilic steroid enters cell via passive diffusion or carrier‑mediated transport.Steroid reaches cytoplasm.
- Nuclear bindingDissociates from heat‑shock protein complexes → binds directly to the intracellular androgen receptor (AR).AR–steroid complex forms.
- DNA transcriptionComplex translocates to nucleus, attaches to androgen response elements (AREs) on target gene promoters.Recruitment of co‑activators (p300/CBP), histone acetyltransferases → chromatin remodeling.
- Gene expressionInitiation of mRNA synthesis for anabolic proteins: IGF‑1, myosin heavy chain, creatine kinase, etc.
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